clinical studies

Randomised, double-blind clinical trial for Simply Nootropics Elevate.

We are currently developing a randomised, double-blind clinical trial to be undertaken in early 2022. As part of this, we are looking for volunteers to be a part of the trial. If this of interest, please email hello@simplynootropics.com with your details, and we will send an application form to you.

 

Clinical Studies On Our Ingredients

 

Ashwagandha

Effect of Ashwagandha on Tests of Cognitive and Psychomotor Performance. Link here.

Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions. Link here.

A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction. Link here.



Algal DHA:

Docosahexaenoic Acid and Cognition throughout the Lifespan. Link here.

DHA improves memory and cognitive function in older adults. Link here.

The benefit of docosahexaenoic acid for the adult brain in aging and dementia. Link here.



Alpha Lipoic Acid (ALA)

The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease. Link here.

Preclinical research suggests that ALA scavenges free radicals, reduces inflammation, and may protect brain cells from conditions such as stroke, multiple sclerosis, and Alzheimer's disease. Link here.

Effect of alpha lipoic acid on cognitive function and oxidative stress. Link here.



Alpha GPC (L-alpha-glycerylphosphorylcholine)

The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility. Link here.

Preclinical studies suggest that alpha-GPC increases the levels of acetylcholine in the brain and can improve cognition in models of memory impairment or brain aging. Link here.

Alpha-GPC and Physical and Cognitive Performances in Volleyball Players. Link here.


Bacopa monnieri (Brahmi)

The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. Link here.

The Neurocognitive Effects of Bacopa monnieri and Cognitive Training on Markers of Brain Microstructure in Healthy Adults. Link here.

Effects of 12-Week Bacopa monnieri Consumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems. Link here.

The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. Link here.



Choline

Effect of Citicoline on Memory Function in Healthy Order Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Link here.

The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort. Link here.

Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes. Link here.



Co Enzyme Q10 

CoQ10 and Cognition a Review and Study Protocol for a 90-Day Randomized Controlled Trial Investigating the Cognitive Effects. Link here.

Influence of Chronic Coenzyme Q10 Supplementation on Cognitive Function, Learning, and Memory. Link here.



Jyothismati (Celastrus Paniculatus)

Neuroprotective effect of Celastrus paniculatus on chronic stress-induced cognitive impairment. Link here. 

Behavioral and Biochemical Evidences for Antidepressant-Like Activity of Celastrus Paniculatus Seed Oil in Mice. Link here.

Cognitive enhancement and Neuroprotective effect of Celastrus paniculatus. Link here.



Ginkgo Extract  

Clinical use of ginkgo biloba extract appears to decrease glucose utilization in brain areas mediating somatosensory processing and vigilance, inhibit stress-induced corticosteroid release. Link here.

An Updated Review of Randomized Clinical Trials Testing the Improvement of Cognitive Function of Ginkgo biloba Extract. Link here.



Vitamin B6

Vitamin B6 deficiency linked to cognitive decline. Link here.

 

Vitamin B—Can it prevent cognitive decline? A systematic review and meta-analysis. Link here.

B-Vitamin Intake and Biomarker Status in Relation to Cognitive Decline. Link here.

The effect of vitamin B6 on cognition. Link here.



L-Theanine  

A double-blind, placebo-controlled study evaluating the effects of L-theanine on cerebral blood flow, cognition and mood. Link here.

Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study. Link here.

Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults. Link here. 



Lion's Mane Mushroom 

Lion’s Mane Mushroom Benefits Memory And Cognition. Link here.

Neuronal Health – Can Culinary and Medicinal Mushrooms Help? Link here.

Lion’s mane mushroom contains a large number of bioactive components and secondary metabolites that have been promoted for healthy benefits ranging from antibiotic, anti-inflammatory, anti-carcinogenic, and neuroprotective properties. Link here.


NMN (Nicotinamide Mononucleotide)

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function. Link here.

Anti-aging compound improves muscle glucose metabolism in people. Link here.

Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment. Link here.

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Link here.



Panax ginseng

A double-masked study of the effects of ginseng on cognitive functions. Link here.

Effect of Panax Ginseng on the Cognitive Performance on memory decline. Link here.

 



NZ Pine bark Extract 

A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people. Link here.

Improved cognitive performance after dietary supplementation with a Pinus radiata bark extract Formulation. Link here.

Nutrition research has shown that Enzogenol (Pine bark) supports healthy brain function, and cognitive performance. Link here.

Comparative effects of enzogenol® and vitamin C supplementation versus vitamin C alone on endothelial function and biochemical markers of oxidative stress and inflammation in chronic smokers. Link here.




Resveratrol

Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults. Link here.

 

Effect of resveratrol on cognitive and memory performance and mood: A meta-analysis of 225 patients. Link here.

Resveratrol and cognitive decline: a clinician perspective. Link here.

Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study. Link here.

 


Rhodiola Rosea

Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms. Link here.

Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event-related potential dual task study. Link here.

The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Link here.

Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men. Link here.



Uridine 5'-monophosphate

Potential Neuroregenerative and Neuroprotective Effects of Uridine/Choline-Enriched Multinutrient Dietary Intervention for Mild Cognitive Impairment: A Narrative Review. Link here.

Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils. Link here.

Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. Link here.

 



Vitamin D3

Vitamin D and cognitive function. Link here.

Effect of vitamin D on cognition in health adults. Link here.

Vitamin D and cognitive function: A Mendelian randomisation study. Link here.

 


Zinc 

Effects of zinc supplementation on cognitive function, cerebral blood flow, and nutritional status in young children at risk of undernutrition: randomized controlled trial. Link here.

Long-Term Effects of Zinc Deficiency and Zinc Supplementation on Developmental Seizure-Induced Brain Damage and the Underlying GPR39/ZnT-3 and MBP Expression in the Hippocampus. Link here.

Effects of zinc supplementation on cognitive function in healthy middle-aged and older adults. Link here.